Table 3 The values of the parameters for model with drug degradation

\(p_{drug}\)

Dose conversion factor

\(7.5*10^{-9}\)

M/(mg/kg)

U

Drug dose rate

5

mg/(kg s)

\(K_a\)

Equilibrium association rate

\(8.5*10^{4}\)

1/M

\(B_{max}\)

Concentration of protein binding sites

\(1.1*10^{-3}\)

M

\(\delta\)

Drug elimination rate

\(5.4*10^{-4}\)

1/s

i

Drug import to cell

\(1.27*10^{8}\)

molec/(s M)

e

Drug export from cell

\(5*10^{-3}\)

1/s