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  1. The degeneration of the intervertebral discs in the lumbar spine is the common cause of neurological and physical dysfunctions and chronic disability of patients, which can be stratified into single—(e.g., dis...

    Authors: Ichiro Nakamoto, Hua Chen, Rui Wang, Yan Guo, Wei Chen, Jie Feng and Jianfeng Wu
    Citation: BioMedical Engineering OnLine 2025 24:11
  2. Respiratory syncytial virus (RSV) is a leading cause of hospitalization for lower respiratory tract infections amongst infants under 1 year, posing a significant global health challenge. The incidence of RSV e...

    Authors: Shuying Wang, Yifan Wang, Yingxue Zou and Cheng-liang Yin
    Citation: BioMedical Engineering OnLine 2025 24:10
  3. Malocclusion, characterized by dental misalignment and improper occlusal relationships, significantly impacts oral health and daily functioning, with a global prevalence of 56%. Lateral cephalogram is a crucia...

    Authors: Qiao Chang, Yuxing Bai, Shaofeng Wang, Fan Wang, Shuang Liang and Xianju Xie
    Citation: BioMedical Engineering OnLine 2025 24:9
  4. Coronavirus disease 19 (COVID-19) patients might develop sequelae after apparent resolution of the infection. Autonomic dysfunction and baroreflex failure have been frequently reported. However, the long-term ...

    Authors: Beatrice Cairo, Francesca Gelpi, Vlasta Bari, Martina Anguissola, Pavandeep Singh, Beatrice De Maria, Marco Ranucci and Alberto Porta
    Citation: BioMedical Engineering OnLine 2025 24:8
  5. Coal workers’ pneumoconiosis is a chronic occupational lung disease with considerable pulmonary complications, including irreversible lung diseases that are too complex to accurately identify via chest X-rays....

    Authors: Hantian Dong, Biaokai Zhu, Xiaomei Kong, Xuesen Su, Ting Liu and Xinri Zhang
    Citation: BioMedical Engineering OnLine 2025 24:7
  6. Recently, the incidence rate and mortality of various acute or chronic vascular occlusive diseases have increased yearly. As one of the most effective measures to treat them, vascular stents have been widely s...

    Authors: Songhao Liu, Juan Yan, Mengyu Gao and Hongxia Yang
    Citation: BioMedical Engineering OnLine 2025 24:6
  7. With precise control of smart materials deformation in time dimension, doctors can customize orthopedic implants. This review focuses on the advances of 4D printing technology in orthopedics, including its app...

    Authors: Chenxi Shen and Aiyong Shen
    Citation: BioMedical Engineering OnLine 2025 24:5
  8. Epidermal growth factor receptor (EGFR) gene mutations can lead to distant metastasis in non-small cell lung cancer (NSCLC). When the primary NSCLC lesions are removed or cannot be sampled, the EGFR status of ...

    Authors: Linyong Wu, Dayou Wei, Songhua Li, Shaofeng Wu, Yan Lin and Lifei Chen
    Citation: BioMedical Engineering OnLine 2025 24:4
  9. Corrective osteotomy for upper limb deformities caused by fractures, trauma, or degeneration necessitates detailed preoperative planning to ensure accurate anatomical alignment, restore limb length, and correc...

    Authors: Yoshii Yuichi, Sho Kohyama, Akira Ikumi, Yohei Yanagisawa, Takushi Nakatani, Junichiro Morita and Takeshi Ogawa
    Citation: BioMedical Engineering OnLine 2025 24:2
  10. A biodegradable nonwoven fabric that can be used to extract adipose-derived stem cells (ADSCs) from adipose tissue slices was developed, which were cultured rapidly without enzymatic treatment. The extracted a...

    Authors: Hiroshi Sunami, Yusuke Shimizu, Hitoshi Nakasone, Naoko Futenma, Junko Denda, Sayaka Yokota, Hidehiro Kishimoto, Masashi Makita and Yasutoshi Nishikawa
    Citation: BioMedical Engineering OnLine 2024 23:133
  11. The aim of this study was to evaluate the feasibility of using a biofeedback-enhanced robotics-assisted tilt table (RATT) to investigate time- and intensity-dependent changes in heart rate variability (HRV) at...

    Authors: Jittima Saengsuwan, Lars Brockmann, Corina Schuster-Amft and Kenneth J. Hunt
    Citation: BioMedical Engineering OnLine 2024 23:132
  12. This study aims to accurately predict the effects of hormonal therapy on prostate cancer (PC) lesions by integrating multi-modality magnetic resonance imaging (MRI) and the clinical marker prostate-specific an...

    Authors: Ibrahim Abdelhalim, Mohamed Ali Badawy, Mohamed Abou El-Ghar, Mohammed Ghazal, Sohail Contractor, Eric van Bogaert, Dibson Gondim, Scott Silva, Fahmi Khalifa and Ayman El-Baz
    Citation: BioMedical Engineering OnLine 2024 23:131
  13. Experimental knee implant wear testing according to ISO 14243 is a standard procedure, but it inherently possesses limitations for preclinical evaluations due to extended testing periods and costly infrastruct...

    Authors: Michael J. Dreyer, Seyyed Hamed Hosseini Nasab, Philippe Favre, Fabian Amstad, Rowena Crockett, William R. Taylor and Bernhard Weisse
    Citation: BioMedical Engineering OnLine 2024 23:130
  14. Stroke is the leading cause of acquired motor deficiencies in adults. Restoring prehension abilities is challenging for individuals who have not recovered active hand opening capacities after their rehabilitat...

    Authors: R. Le Guillou, J. Froger, M. Morin, M. Couderc, C. Cormier, C. Azevedo-Coste and D. Gasq
    Citation: BioMedical Engineering OnLine 2024 23:129
  15. Chemotherapy-induced cardiotoxicity is a significant concern in cancer treatment, as certain chemotherapeutic agents can have adverse effects on the cardiovascular system. This can lead to a range of cardiac c...

    Authors: Hadi Zare-Zardini, Mohammad-Taghi Hedayati-Goudarzi, Ameneh Alizadeh, Fatemeh Sadeghian-Nodoushan and Hossein Soltaninejad
    Citation: BioMedical Engineering OnLine 2024 23:128
  16. Despite the development of various therapeutic approaches over the past decades, the treatment of glioblastoma multiforme (GBM) remains a major challenge. The extracellular adenosine-generating enzyme, CD73, i...

    Authors: Marjan Bahraminasab, Samira Asgharzade, Ali Doostmohamadi, Atefeh Satari, Farkhonde Hasannejad and Samaneh Arab
    Citation: BioMedical Engineering OnLine 2024 23:127
  17. Spinal cord injury (SCI) often leads to the loss of urinary sensation, making urination difficult. In a previous experiment involving six healthy participants, we measured heartbeat-induced acoustic pulse wave...

    Authors: Hitomi Suzuki, Hiroji Tsujimura, Teruyo Kitahara, Kazushi Taoda, Yumi Ogura and Etsunori Fujita
    Citation: BioMedical Engineering OnLine 2024 23:126
  18. To explore the expression of periostin in the epithelium of cholesteatoma with different destruction degrees of the ossicular chain and its clinical value in predicting postoperative hearing recovery.

    Authors: Cuncun Xie, Xiaodong Jia, Shaoguang Ding, Xiaoli Ding, Guangke Wang and Hongjian Liu
    Citation: BioMedical Engineering OnLine 2024 23:125
  19. Chronic venous insufficiency (CVI) is a common disease with a high prevalence. Incompetent venous valves are considered as one of the main causes. Besides compression therapy, various surgical therapies are pr...

    Authors: Andreas Götz, Sabine Illner, Nicklas Fiedler, Julia Schubert, Jan Oldenburg, Heinz Müller, Wolfram Schmidt, Klaus-Peter Schmitz, Niels Grabow and Kerstin Lebahn
    Citation: BioMedical Engineering OnLine 2024 23:124
  20. Acute ischemic stroke (AIS) remains a major cause of morbidity and mortality worldwide. Mechanical thrombectomy, especially with stent retrievers, offers a promising treatment, particularly for patients inelig...

    Authors: Jae-Won Lee, Han-Ki Kim, JinWoo Kim and Hyuk Choi
    Citation: BioMedical Engineering OnLine 2024 23:121
  21. Primary osteoporosis has increasingly emerged as a major issue affecting human health, with a complex specific pathogenic mechanism. As a research hotspot, ferroptosis plays a vital role in the pathogenesis of...

    Authors: Hui Su, Guoqing Tan, WenXuan Guo, Jin Sheng Yu, Zhanwang Xu, RuJie Zhuang and Haipeng Xue
    Citation: BioMedical Engineering OnLine 2024 23:120
  22. This study investigates the effects of hexagonal microtextured titanium sheets on fibroblast growth and collagen synthesis, crucial factors in anastomotic healing.

    Authors: Haoyu He, Peiyao Wang, Zhuo Liu, Rongchuan Feng, Bang Liu, Qiang Song, Yahui Hu and Weihua Fu
    Citation: BioMedical Engineering OnLine 2024 23:119
  23. Blister aneurysms of the internal carotid artery (ICA) are rare and are primarily documented in the literature through small series and case reports. The intraoperative observation of a hemorrhage in the arter...

    Authors: Tristan Martin, Gilles El Hage, Claude Barbeau and Michel W. Bojanowski
    Citation: BioMedical Engineering OnLine 2024 23:118
  24. This study aimed to develop and validate an ultrasound radiomics model for distinguishing invasive ductal carcinoma (IDC) from ductal carcinoma in situ (DCIS) by combining intratumoral and peritumoral features.

    Authors: Heng Zhang, Tong Zhao, Jiangyi Ding, Ziyi Wang, Nannan Cao, Sai Zhang, Kai Xie, Jiawei Sun, Liugang Gao, Xiaoqin Li and Xinye Ni
    Citation: BioMedical Engineering OnLine 2024 23:117
  25. Extracellular vesicles (EVs) have emerged as an exciting tool for targeted delivery of therapeutics for a wide range of diseases. As nano-scale membrane-bound particles derived from living cells, EVs possess i...

    Authors: Corinna Torabi, Sung-Eun Choi, Thomas R. Pisanic, Michael Paulaitis and Soojung Claire Hur
    Citation: BioMedical Engineering OnLine 2024 23:116
  26. Sarcopenia is an age-related, insidious, crippling but curable degenerative disease if diagnosed and treated early. However, no accessible and accurate early screening method is available for community setting...

    Authors: Haoru He, Xiaochu Wu, Na Li, Yi Jiang, Jiayuan He and Ning Jiang
    Citation: BioMedical Engineering OnLine 2024 23:115
  27. Heart disease patients necessitate precise monitoring to ensure the safety and efficacy of their physical activities when managing conditions such as hypertension or heart failure. This study, therefore, aimed...

    Authors: Tara Vijgeboom, Marjolein Muller, Kambiz Ebrahimkheil, Casper van Eijck and Eelko Ronner
    Citation: BioMedical Engineering OnLine 2024 23:114
  28. Vascular transplantation is an effective treatment for severe vascular lesions. The design of the bioactive and mechanical properties of small-caliber vascular grafts is critical for their application in tissu...

    Authors: Jiayi Wu, Yixin Chen, Xiaoxi Liu, Shun Liu, Long Deng and Kai Tang
    Citation: BioMedical Engineering OnLine 2024 23:112
  29. Oral health is closely linked to systemic conditions, particularly non-communicable diseases (NCDs), which can exacerbate oral issues. Essential oils (EOs) have emerged as potential alternatives for oral healt...

    Authors: Karunan Joseph, Bojan Petrović, Syarifah Aisyah Syed Ibrahim, Aung Thiha, Lazar Milić, Mohd Yazed Ahmad, Nebojša Pavlović, Sanja Kojić, Fatimah Ibrahim and Goran M. Stojanović
    Citation: BioMedical Engineering OnLine 2024 23:111
  30. The purpose of this study was to evaluate the repeatability and agreement of multispectral refraction topography (MRT) in measuring retinal refraction before and after cycloplegia in children. The results of t...

    Authors: Xiaoli Xu, Wansheng Zang, Anken Wang and Chenhao Yang
    Citation: BioMedical Engineering OnLine 2024 23:110
  31. Alzheimer’s disease (AD) is a chronic disease among people aged 65 and older. As the aging population continues to grow at a rapid pace, AD has emerged as a pressing public health issue globally. Early detecti...

    Authors: Guosheng Shen, Fei Ye, Wei Cheng and Qiang Li
    Citation: BioMedical Engineering OnLine 2024 23:109
  32. This article provides an overview of recent progress in the achievement of non-contact intraoperative image control through the use of vision and sensor technologies in operating room (OR) environments. A disc...

    Authors: Zhengnan Liu, Chengrun Li, Jixing Lin, Hengliang Xu, Yan Xu, Haoning Nan, Wei Cheng, Jie Li and Bin Wang
    Citation: BioMedical Engineering OnLine 2024 23:108
  33. The probability density function (PDF) of the surface electromyogram (sEMG) depends on contraction force. This dependence, however, has so far been investigated by having the subject generate force at a few fi...

    Authors: Javier Rodriguez-Falces, Armando Malanda, Cristina Mariscal, Silvia Recalde and Javier Navallas
    Citation: BioMedical Engineering OnLine 2024 23:106
  34. Manually bent, standard-of-care, Ti–6Al–4V, mandibular graft fixation devices are associated with a significant post-operative failure rate. These failures require the patient to endure stressful and expensive...

    Authors: Nada Raafat Khattab, Luis H. Olivas-Alanis, Agnieszka Chmielewska-Wysocka, Hany Emam, Ryan Brune, Ahmadreza Jahadakbar, Sahil Khambhampati, Joseph Lozier, Keyvan Safaei, Roman Skoracki, Mohammad Elahinia and David Dean
    Citation: BioMedical Engineering OnLine 2024 23:105
  35. Multiphase information fusion and spatiotemporal feature modeling play a crucial role in the task of four-phase CT lesion recognition. In this paper, we propose a four-phase CT lesion recognition algorithm bas...

    Authors: Shaohua Qiao, Mengfan Xue, Yan Zuo, Jiannan Zheng, Haodong Jiang, Xiangai Zeng and Dongliang Peng
    Citation: BioMedical Engineering OnLine 2024 23:103
  36. The use of human dental pulp stem cells (hDPSCs) as autologous stem cells for tissue repair and regenerative techniques is a significant area of global research. The objective of this study was to investigate ...

    Authors: Jidong Xu, Mingchang Hu, Longfei Liu, Xuecheng Xu, Linlin Xu and Yu Song
    Citation: BioMedical Engineering OnLine 2024 23:102
  37. Peri-implantitis (PI), a pathological condition associated with plaque, affects the tissues around dental implants. In addition, peri-implant mucositis (PIM) is a precursor to the destructive inflammatory PI a...

    Authors: Mohammad Hosseini Hooshiar, Asieh Mozaffari, Mareb Hamed Ahmed, Radhwan Abdul Kareem, Athmar Jaber Zrzo, Aseel Salah Mansoor, Zainab H. Athab, Zahra Parhizgar and Parisa Amini
    Citation: BioMedical Engineering OnLine 2024 23:101
  38. Diseases of the esophagus affect its function and often lead to replacement of long sections of the organ. Current healing methods involve the use of bioscaffolds processed from other animal models. Although t...

    Authors: H. M. Ngwangwa, D. Modungwa, T. Pandelani and F. J. Nemavhola
    Citation: BioMedical Engineering OnLine 2024 23:100
  39. Developmental dysplasia of the hip (DDH) is a common pediatric orthopedic condition characterized by varying degrees of acetabular dysplasia and hip dislocation. Current 2D imaging methods often fail to provid...

    Authors: Dian Zhang, Hongyan Zhou, Tianli Zhou, Yan Chang, Lei Wang, Mao Sheng, Huihui Jia and Xiaodong Yang
    Citation: BioMedical Engineering OnLine 2024 23:98
  40. This retrospective aims to develop a comprehensive predictive model based on CT radiomic features and clinical parameters, facilitating early preoperative diagnosis of pyonephrosis.

    Authors: Yongchao Yan, Yunbo Liu, Yize Guo, Bin Li, Yanjiang Li and Xinning Wang
    Citation: BioMedical Engineering OnLine 2024 23:97
  41. This review aims to comprehensively explore calcium-enriched mixture (CEM) cement as a crucial biomaterial in dentistry/endodontics. With its growing clinical relevance, there is a need to evaluate its composi...

    Authors: Saeed Asgary, Mahtab Aram and Mahta Fazlyab
    Citation: BioMedical Engineering OnLine 2024 23:96
  42. Anomalous origin of coronary artery is a common coronary artery anatomy anomaly. The anomalous origin of the coronary artery may lead to problems such as narrowing of the coronary arteries at the beginning of ...

    Authors: Ying Wang, MengXing Wang, Mingyuan Yuan and Wenxian Peng
    Citation: BioMedical Engineering OnLine 2024 23:95